Utilization of protein intrinsic disorder knowledge in structural proteomics.

ABSTRACT: Intrinsically disordered proteins (IDPs) and proteins with long disordered regions are highly abundant in various proteomes. Despite their lack of well-defined ordered structure, these proteins and regions are frequently involved in crucial biological processes. Although in recent years these proteins have attracted the attention of many researchers, IDPs represent a significant challenge for structural characterization since these proteins can impact many of the processes in the structure determination pipeline. Here we investigate the effects of IDPs on the structure determination process and the utility of disorder prediction in selecting and improving proteins for structural characterization. Examination of the extent of intrinsic disorder in existing crystal structures found that rela

SUBMITTER: Oldfield CJ 

PROVIDER: S-EPMC3951342 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature