Novel LanT associated lantibiotic clusters identified by genome database mining.

ABSTRACT:

Background

Frequent use of antibiotics has led to the emergence of antibiotic resistance in bacteria. Lantibiotic compounds are ribosomally synthesized antimicrobial peptides against which bacteria are not able to produce resistance, hence making them a good alternative to antibiotics. Nisin is the oldest and the most widely used lantibiotic, in food preservation, without having developed any significant resistance against it. Having their antimicrobial potential and a limited number, there is a need to identify novel lantibiotics.

Methodology/findings

Identification of novel lantibiotic biosynthetic clusters from an ever increasing database of bacterial genomes, can provide a major lead in this direction. In order to achieve this, a strategy was adopted to identify novel la

SUBMITTER: Singh M 

PROVIDER: S-EPMC3951391 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature