Contributions of orbitofrontal and lateral prefrontal cortices to economic choice and the good-to-action transformation.

ABSTRACT: Previous work indicates that economic decisions can be made independently of the visuomotor contingencies of the choice task (space of goods). However, the neuronal mechanisms through which the choice outcome (the chosen good) is transformed into a suitable action plan remain poorly understood. Here we show that neurons in lateral prefrontal cortex reflect the early stages of this good-to-action transformation. Monkeys chose between different juices. The experimental design dissociated in space and time the presentation of the offers and the saccade targets associated with them. We recorded from the orbital, ventrolateral, and dorsolateral prefrontal cortices (OFC, LPFCv, and LPFCd, respectively). Prior to target presentation, neurons in both LPFCv and LPFCd encoded the choice outcome in g

SUBMITTER: Cai X 

PROVIDER: S-EPMC3951647 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature