Role of the Mce1 transporter in the lipid homeostasis of Mycobacterium tuberculosis.

ABSTRACT: Tuberculosis is one of the leading causes of mortality throughout the world. Mycobacterium tuberculosis, the causative agent of human tuberculosis, has developed several strategies involving proteins and other compounds known collectively as virulence factors to subvert human host defences and invade the human host. The Mce proteins are among these virulence-related proteins and are encoded by the mce1, mce2, mce3 and mce4 operons in the genome of M. tuberculosis. It has been proposed that these operons encode ABC-like lipid transporters; however, the nature of their substrates has only been revealed in the case of the Mce4 proteins. Here we found that the knockout of the mce1 operon alters the lipid profile of M. tuberculosis H37Rv and the uptake of palmitic acid. Thin layer chromatograph

SUBMITTER: Forrellad MA 

PROVIDER: S-EPMC3951760 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature