Alterations of intestinal serotonin following nanoparticle exposure in embryonic zebrafish.

ABSTRACT: The increased use of engineered nanoparticles (NPs) in manufacturing and consumer products raises concerns about the potential environmental and health implications on the ecosystem and living organisms. Organs initially and more heavily affected by environmental NPs exposure in whole organisms are the skin and digestive system. We investigate the toxic effect of two types of NPs, nickel (Ni) and copper oxide (CuO), on the physiology of the intestine of a living aquatic system, zebrafish embryos. Embryos were exposed to a range of Ni and CuO NP concentrations at different stages of embryonic development. We use changes in the physiological serotonin (5HT) concentrations, determined electrochemically with carbon fiber microelectrodes inserted in the live embryo, to assess this organ dysfunc

SUBMITTER: Ozel RE 

PROVIDER: S-EPMC3951830 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature