Comparative proteome analysis revealing an 11-protein signature for aggressive triple-negative breast cancer.

ABSTRACT:

Background

Clinical outcome of patients with triple-negative breast cancer (TNBC) is highly variable. This study aims to identify and validate a prognostic protein signature for TNBC patients to reduce unnecessary adjuvant systemic therapy.

Methods

Frozen primary tumors were collected from 126 lymph node-negative and adjuvant therapy-naive TNBC patients. These samples were used for global proteome profiling in two series: an in-house training (n = 63) and a multicenter test (n = 63) set. Patients who remained free of distant metastasis for a minimum of 5 years after surgery were defined as having good prognosis. Cox regression analysis was performed to develop a prognostic signature, which was independently validated. All statistical tests were two-sided.

Results

An 1

SUBMITTER: Liu NQ 

PROVIDER: S-EPMC3952199 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature