Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.

ABSTRACT:

Background

Blood pressure (BP) responses to dietary sodium and potassium intervention and cold pressor test vary considerably among individuals. We aimed to identify novel genetic variants influencing individuals' BP responses to dietary intervention and cold pressor test.

Methods and results

We conducted a genome-wide association study of BP responses in 1881 Han Chinese and de novo genotyped top findings in 698 Han Chinese. Diet-feeding study included a 7-day low-sodium (51.3 mmol/d), a 7-day high-sodium (307.8 mmol/d), and a 7-day high-sodium plus potassium supplementation (60 mmol/d). Nine BP measurements were obtained during baseline observation and each intervention period. The meta-analyses identified 8 novel loci for BP phenotypes, which physically mapped in or near

SUBMITTER: He J 

PROVIDER: S-EPMC3952335 | biostudies-literature | 2013 Dec

REPOSITORIES: biostudies-literature