Active surveillance versus surgery for low risk prostate cancer: a clinical decision analysis.

ABSTRACT:

Purpose

We assessed the effect of age, health status and patient preferences on outcomes of surgery vs active surveillance for low risk prostate cancer.

Materials and methods

We used Monte Carlo simulation of Markov models of the life courses of 200,000 men diagnosed with low risk prostate cancer and treated with surveillance or radical prostatectomy to calculate quality adjusted life expectancy, life expectancy, prostate cancer specific mortality and years of treatment side effects, with model parameters derived from the literature. We simulated outcomes for men 50 to 75 years old with poor, average or excellent health status (50%, 100% and 150% of average life expectancy, respectively). Sensitivity of outcomes to uncertainties in model parameters was tested.

Results

SUBMITTER: Liu D 

PROVIDER: S-EPMC3952430 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature