Decorin and biglycan retain LDL in disease-prone valvular and aortic subendothelial intimal matrix.

ABSTRACT:

Objective

Subendothelial LDL retention by intimal matrix proteoglycans is an initial step in atherosclerosis and calcific aortic valve disease. Herein, we identify decorin and biglycan as the proteoglycans that preferentially retain LDL in intimal matrix at disease-prone sites in normal valve and vessel wall.

Methods

The porcine aortic valve and renal artery ostial diverter, initiation sites of calcific valve disease and renal atherosclerosis, respectively, from normal non-diseased animals were used as models in these studies.

Results

Fluorescent human LDL was selectively retained on the lesion-prone collagen/proteoglycan-enriched aortic surface of the valve, where the elastic lamina is depleted, as previously observed in lesion-prone sites in the renal ostium. iTRAQ

SUBMITTER: Neufeld EB 

PROVIDER: S-EPMC3952492 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature