Intracellular Theileria annulata promote invasive cell motility through kinase regulation of the host actin cytoskeleton.

ABSTRACT: The intracellular, protozoan Theileria species parasites are the only eukaryotes known to transform another eukaryotic cell. One consequence of this parasite-dependent transformation is the acquisition of motile and invasive properties of parasitized cells in vitro and their metastatic dissemination in the animal, which causes East Coast Fever (T. parva) or Tropical Theileriosis (T. annulata). These motile and invasive properties of infected host cells are enabled by parasite-dependent, poorly understood F-actin dynamics that control host cell membrane protrusions. Herein, we dissected functional and structural alterations that cause acquired motility and invasiveness of T. annulata-infected cells, to understand the molecular basis driving cell dissemination in Tropical Theileriosis. We fo

SUBMITTER: Ma M 

PROVIDER: S-EPMC3953445 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature