Mutual regioselective inhibition of human UGT1A1-mediated glucuronidation of four flavonoids.

ABSTRACT: UDP-glucuronosyltransferase (UGT) 1A1-catalyzed glucuronidation is an important elimination pathway of flavonoids, and mutually inhibitory interactions may occur when two or more flavonoids are coadministered. Our recent research suggested that glucuronidation of flavonoids displayed distinct positional preferences, but whether this will lead to the mutually regioselective inhibition of UGT1A1-mediated glucuronidation of flavonoids is unknown. Therefore, we chose three monohydroxyflavone isomers, 3-hydroxyflavone (3HF), 7-hydroxyflavone (7HF), and 4'-hydroxyflavone (4'HF), and one trihydroxyflavone, 3,7,4'-trihydroxyflavone (3,7,4'THF), as the model compounds to characterize the possible mutually regioselective inhibition of glucuronidation using expressed human UGT1A1. Apparent kinetic pa

SUBMITTER: Ma G 

PROVIDER: S-EPMC3953455 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature