Autophagy-related IRGM polymorphism is associated with mortality of patients with severe sepsis.

ABSTRACT:

Objective

Autophagy is the regulated catabolic process for recycling damaged or unnecessary organelles, which plays crucial roles in cell survival during nutrient deficiency, and innate immune defense against pathogenic microorganisms. Autophagy has been also reported to be involved in various conditions including inflammatory diseases. IRGM (human immunity-related GTPase) has an important function in eliminating Mycobacterium tuberculosis from host cells via autophagy. We examined the association between genetic polymorphism and clinical course/outcome in severely septic patients.

Methods

The study included 125 patients with severe sepsis/septic shock (SS) and 104 non-sepsis patients who were admitted to the intensive care unit (ICU) of Chiba University Hospital between Oct

SUBMITTER: Kimura T 

PROVIDER: S-EPMC3953488 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature