Does loop electrosurgical excision procedure of the uterine cervix affect anti-Mullerian hormone levels?

ABSTRACT:

Background

A delayed time to pregnancy was recently reported for women who had a loop electrosurgical excision procedure (LEEP) to remove cervical intraepithelial neoplasia (CIN) grade 2 or 3. The objective of the current study was to determine if treatment of CIN with LEEP is associated with decreased levels of anti-Müllerian hormone (AMH), a marker of ovarian reserve.

Methods

AMH levels were measured in 18 women treated with LEEP and 18 age-matched controls, who had colposcopy only and did not require LEEP. Cases and controls had their blood drawn at study entry time zero and again 6 months later.

Results

The mean AMH level decreased significantly from baseline to follow-up; however, no significant differences were observed when stratifying by LEEP status, suggestin

SUBMITTER: Sklavos MM 

PROVIDER: S-EPMC3953513 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature