Prognostic value of circulating microRNA-210 levels in patients with moderate to severe aortic stenosis.

ABSTRACT:

Background

Circulating micro-RNAs have been proposed as a novel class of cardiovascular (CV) biomarkers, but whether they meet analytical requirements and provide additional information to establish risk indices have not been established. miR-210 levels are increased in subjects with low VO2 max, which is a recognized risk factor in patients with aortic stenosis (AS), and we hypothesized that circulating miR-210 levels may be increased in patients with AS and associated with a poor prognosis.

Methods

We measured circulating miR-210 levels by real-time PCR in 57 patients with moderate to severe AS and in 10 age- and gender-matched healthy controls. The merit of miR-210 as a biomarker was assessed according to established criteria, including by comparing miR-210 levels with NT

SUBMITTER: Rosjo H 

PROVIDER: S-EPMC3953554 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature