Biomarker-calibrated protein intake and bone health in the Women's Health Initiative clinical trials and observational study.

ABSTRACT:

Background

The effects of dietary protein on bone health are controversial.

Objective

We examined the relation between protein intake with fracture and bone mineral density (BMD) within the Women's Health Initiative (WHI).

Design

This prospective analysis included 144,580 women aged 50-79 y at baseline in the WHI clinical trials (CTs) and observational study (OS) that recruited participants in 1993-1998 with follow-up through 2011. Self-reported clinical fractures were collected semiannually through the original end of the trials (WHI CTs) and annually (WHI OS) by questionnaires. Hip fracture was adjudicated by a central review of radiology reports. BMDs for total body, hip, and spine were measured at baseline and 3 and 6 y in 9062 women at 3 WHI clinics by using dual

SUBMITTER: Beasley JM 

PROVIDER: S-EPMC3953886 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature