Treatment of obstructive sleep apnea alters cancer-associated transcriptional signatures in circulating leukocytes.

ABSTRACT:

Rationale

Obstructive sleep apnea (OSA) has been associated with a number of chronic disorders that may improve with effective therapy. However, the molecular pathways affected by continuous positive airway pressure (CPAP) treatment are largely unknown. We sought to assess the system-wide consequences of CPAP therapy by transcriptionally profiling peripheral blood leukocytes (PBLs).

Methods

Subjects in whom severe OSA was diagnosed were treated with CPAP, and whole-genome expression measurement of PBLs was performed at baseline and following therapy. We used gene set enrichment analysis (GSEA) to identify pathways that were differentially enriched. Network analysis was then applied to highlight key drivers of processes influenced by CPAP.

Results

Eighteen subjects wit

SUBMITTER: Gharib SA 

PROVIDER: S-EPMC3954174 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature