High dosage of hypnotics predicts subsequent sleep-related breathing disorders and is associated with worse outcomes for depression.

ABSTRACT:

Objectives

The rates of sleep related breathing disorders (SRBD) and treatment outcomes of depression were compared among insomnia patients who had stratified levels of hypnotic use during a 10-year follow-up (2001-2010).

Design

A nationwide population-based cohort study.

Setting

A nationally representative cohort of 1,000,000 enrollees.

Participants

Data were collected from patients with major depressive disorder (MDD) and comorbid insomnia during January 2001 to December 2003 (study cohort N = 3,235). The mean dosage of hypnotics at baseline in the study cohort was calculated, and this information was used to categorize the cohort into three equal-sized groups based on levels of hypnotic dosage.

Main outcome measures

Patient response to antidepressants

SUBMITTER: Li CT 

PROVIDER: S-EPMC3954175 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature