Variable selection and prediction using a nested, matched case-control study: Application to hospital acquired pneumonia in stroke patients.

ABSTRACT: Matched case-control designs are commonly used in epidemiologic studies for increased efficiency. These designs have recently been introduced to the setting of modern imaging and genomic studies, which are characterized by high-dimensional covariates. However, appropriate statistical analyses that adjust for the matching have not been widely adopted. A matched case-control study of 430 acute ischemic stroke patients was conducted at Massachusetts General Hospital (MGH) in order to identify specific brain regions of acute infarction that are associated with hospital acquired pneumonia (HAP) in these patients. There are 138 brain regions in which infarction was measured, which introduce nearly 10,000 two-way interactions, and challenge the statistical analysis. We investigate penalized condi

SUBMITTER: Qian J 

PROVIDER: S-EPMC3954429 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature