Genomic analyses of RH alleles to improve transfusion therapy in patients with sickle cell disease.

ABSTRACT:

Background

Red cell (RBC) blood group alloimmunization remains a major problem in transfusion medicine. Patients with sickle cell disease (SCD) are at particularly high risk for developing alloantibodies to RBC antigens compared to other multiply transfused patient populations. Hemagglutination is the classical method used to test for blood group antigens, but depending on the typing methods and reagents used may result in discrepancies that preclude interpretation based on serologic reactivity alone. Molecular methods, including customized DNA microarrays, are increasingly used to complement serologic methods in predicting blood type. The purpose of this study was to determine the diversity and frequency of RH alleles in African Americans and to assess the performance of a DNA mic

SUBMITTER: Reid ME 

PROVIDER: S-EPMC3954443 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature