Pd-catalyzed nucleophilic fluorination of aryl bromides.

ABSTRACT: On the basis of mechanism-driven reaction design, a Pd-catalyzed nucleophilic fluorination of aryl bromides and iodides has been developed. The method exhibits a broad substrate scope, especially with respect to nitrogen-containing heteroaryl bromides, and proceeds with minimal formation of the corresponding reduction products. A facilitated ligand modification process was shown to be critical to the success of the reaction.

SUBMITTER: Lee HG 

PROVIDER: S-EPMC3954505 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature