Elevated interleukin-32 expression is associated with Helicobacter pylori-related gastritis.

ABSTRACT:

Background

Interleukin-32 (IL-32) is a recently discovered proinflammatory cytokine involved in inflammatory diseases. We investigated the expression of IL-32 and its regulation mechanism in the inflammatory response of patients with Helicobacter pylori (H. pylori) infection.

Design and methods

IL-32 mRNA and protein expression in gastric tissues was detected by quantitative real-time PCR and immunohistochemistry. The regulation of IL-32 in human gastric epithelia cell line AGS was investigated by different cytokine stimulation and different H. pylori strain infection.

Results

Gastric IL-32 mRNA and protein expression were elevated in patients with H. pylori infection and positively correlated with gastritis. In H. pylori-infected patients, the mRNA level of IL-32 was

SUBMITTER: Peng LS 

PROVIDER: S-EPMC3954549 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature