A Crowdsourced nucleus: understanding nuclear organization in terms of dynamically networked protein function.

ABSTRACT: The spatial organization of the nucleus results in a compartmentalized structure that affects all aspects of nuclear function. This compartmentalization involves genome organization as well as the formation of nuclear bodies and plays a role in many functions, including gene regulation, genome stability, replication, and RNA processing. Here we review the recent findings associated with the spatial organization of the nucleus and reveal that a common theme for nuclear proteins is their ability to participate in a variety of functions and pathways. We consider this multiplicity of function in terms of Crowdsourcing, a recent phenomenon in the world of information technology, and suggest that this model provides a novel way to synthesize the many intersections between nuclear organization an

SUBMITTER: Wood AM 

PROVIDER: S-EPMC3954575 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature