Ketogenic diets enhance oxidative stress and radio-chemo-therapy responses in lung cancer xenografts.

ABSTRACT:

Purpose

Ketogenic diets are high in fat and low in carbohydrates as well as protein which forces cells to rely on lipid oxidation and mitochondrial respiration rather than glycolysis for energy metabolism. Cancer cells (relative to normal cells) are believed to exist in a state of chronic oxidative stress mediated by mitochondrial metabolism. The current study tests the hypothesis that ketogenic diets enhance radio-chemo-therapy responses in lung cancer xenografts by enhancing oxidative stress.

Experimental design

Mice bearing NCI-H292 and A549 lung cancer xenografts were fed a ketogenic diet (KetoCal 4:1 fats: proteins+carbohydrates) and treated with either conventionally fractionated (1.8-2 Gy) or hypofractionated (6 Gy) radiation as well as conventionally fractionated rad

SUBMITTER: Allen BG 

PROVIDER: S-EPMC3954599 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature