Efficacy of combination therapy with oseltamivir phosphate and azithromycin for influenza: a multicenter, open-label, randomized study.

ABSTRACT:

Background

Macrolides have antibiotic and immunomodulatory activities, which may have a favorable effect on the clinical outcome of patients with infections, including influenza. This study aimed to evaluate the effects of combination therapy with an anti-influenza agent, oseltamivir, and a single-dose formulation of azithromycin (AZM), which has been used for influenza-related secondary pneumonia, on influenza patients. The primary endpoint was a change in the expression levels of inflammatory cytokines. Secondary endpoints were the time required for resolution of influenza-related symptoms, incidence of complications, and adverse reactions.

Methods

Patients with seasonal influenza were enrolled in this multicenter, open-label, randomized study. Patients were stratified acc

SUBMITTER: Kakeya H 

PROVIDER: S-EPMC3954629 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature