Ontology highlight
ABSTRACT:
SUBMITTER: Cannone V
PROVIDER: S-EPMC3954783 | biostudies-literature | 2013 Nov
REPOSITORIES: biostudies-literature
Cannone Valentina V Huntley Brenda K BK Olson Timothy M TM Heublein Denise M DM Scott Christopher G CG Bailey Kent R KR Redfield Margaret M MM Rodeheffer Richard J RJ Burnett John C JC
Hypertension (Dallas, Tex. : 1979) 20130916 5
We analyzed the phenotype associated with the atrial natriuretic peptide (ANP) genetic variant rs5065 in a random community-based sample. We also assessed and compared the biological action of 2 concentrations (10(-10) mol/L, 10(-8) mol/L) of ANP and ANP-RR, the protein variant encoded by the minor allele of rs5065, on activation of the guanylyl cyclase (GC)-A and GC-B receptors, production of the second messenger 3',5'-cGMP in endothelial cells, and endothelial permeability. rs5065 genotypes we ...[more]