Allopurinol is an independent determinant of improved arterial stiffness in chronic kidney disease: a cross-sectional study.

ABSTRACT:

Background

Arterial stiffness is increased in patients with CKD and is a powerful predictor of cardiovascular morbidity and mortality. Use of the xanthine oxidase inhibitor allopurinol has been shown to improve endothelial function, reduce left ventricular hypertrophy and possibly improve cardiovascular outcome. We explored the relationship between use of allopurinol and arterial stiffness in patients with chronic kidney disease (CKD).

Methods

Cross-sectional observational study of 422 patients with CKD with evidence of, or at high risk of, renal disease progression. Arterial stiffness was determined by carotid-femoral pulse wave velocity (PWV).

Results

The mean age was 63 ± 16 years, median estimated glomerular filtration rate was 25 (interquartile range: 19-31) ml/m

SUBMITTER: Ng KP 

PROVIDER: S-EPMC3954864 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature