Mangiferin has an additive effect on the apoptotic properties of hesperidin in Cyclopia sp. tea extracts.

ABSTRACT: A variety of biological pro-health activities have been reported for mangiferin and hesperidin, two major phenolic compounds of Honeybush (Cyclopia sp.) tea extracts. Given their increasing popularity, there is a need for understanding the mechanisms underlying the biological effects of these compounds. In this study, we used real-time cytotoxicity cellular analysis of the Cyclopia sp. extracts on HeLa cells and found that the higher hesperidin content in non-fermented "green" extracts correlated with their higher cytotoxicity compared to the fermented extracts. We also found that mangiferin had a modulatory effect on the apoptotic effects of hesperidin. Quantitative PCR analysis of hesperidin-induced changes in apoptotic gene expression profile indicated that two death receptor pathway me

SUBMITTER: Bartoszewski R 

PROVIDER: S-EPMC3954868 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature