Fibroblasts from long-lived species of mammals and birds show delayed, but prolonged, phosphorylation of ERK.

ABSTRACT: Fibroblasts from long-lived mutant mice show diminished phosphorylation of the stress-activated protein kinases ERK1/2 after exposure to peroxide, cadmium, or paraquat. We have now evaluated the kinetics of ERK phosphorylation in fibroblasts from long-lived and short-lived species of mammals and birds in response to stress by cadmium or hydrogen peroxide. Fibroblasts from the shorter-lived species of rodents and birds showed rapid induction of ERK phosphorylation, with a decline to basal level within 60 min. In contrast, cells from longer-lived species showed slower and more prolonged activation of ERK phosphorylation. These results suggest that fibroblasts from long-lived species may be less susceptible to the early phases of damage from cadmium or peroxide and suggest that altered kineti

SUBMITTER: Elbourkadi N 

PROVIDER: S-EPMC3954945 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature