Genetic susceptibility to type 2 diabetes and obesity: follow-up of findings from genome-wide association studies.

ABSTRACT: Elucidating the underlying genetic variations influencing various complex diseases is one of the major challenges currently facing clinical genetic research. Although these variations are often difficult to uncover, approaches such as genome-wide association studies (GWASs) have been successful at finding statistically significant associations between specific genomic loci and disease susceptibility. GWAS has been especially successful in elucidating genetic variants that influence type 2 diabetes (T2D) and obesity/body mass index (BMI). Specifically, several GWASs have confirmed that a variant in transcription factor 7-like 2 (TCF7L2) confers risk for T2D, while a variant in fat mass and obesity-associated protein (FTO) confers risk for obesity/BMI; indeed both of these signals are consid

SUBMITTER: Basile KJ 

PROVIDER: S-EPMC3955626 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature