Liposome surface functionalization based on different anchoring lipids via Staudinger ligation.

ABSTRACT: Liposome surface functionalization facilitates numerous potential applications of liposomes, such as enhanced stability, bioactive liposome conjugates, and targeted drug, gene and image agent delivery. Anchoring lipids are needed for grafting ligands of interest and play important roles in ligand grafting density, liposome stability, and liposome chemical and physical characteristics as well. In this report, glyco-functionalized liposome systems based on two kinds of anchoring lipids, phosphatidylethanolamine (PE) and cholesterol (Chol), were prepared by post chemically selective functionalization via Staudinger ligation. The size and stability of the liposomes were confirmed by dynamic light scattering (DLS). Particularly, the impact of anchor lipids on the stability of glyco-functionaliz

SUBMITTER: Vabbilisetty P 

PROVIDER: S-EPMC3955738 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature