Cognitive characteristics of PTEN hamartoma tumor syndromes.

ABSTRACT:

Purpose

We sought to characterize cognition in individuals with germline PTEN mutations (n = 23) as well as in PTEN mutation-negative individuals with classic Cowden syndrome or Bannayan-Riley-Ruvalcaba syndrome (n = 2).

Methods

Twenty-five individuals completed a comprehensive neuropsychological evaluation. One sample t-tests and effect sizes were used to examine differences in participant test scores compared with normal controls. Composite scores were created for each patient within each of the cognitive domains assessed and classified as above average, average, or below average according to normative standards. χ(2) analyses compared these classifications to expected proportions in normal control samples.

Results

The mean intelligence quotient was in the average r

SUBMITTER: Busch RM 

PROVIDER: S-EPMC3956109 | biostudies-literature | 2013 Jul

REPOSITORIES: biostudies-literature