Mathematical model of adult stem cell regeneration with cross-talk between genetic and epigenetic regulation.

ABSTRACT: Adult stem cells, which exist throughout the body, multiply by cell division to replenish dying cells or to promote regeneration to repair damaged tissues. To perform these functions during the lifetime of organs or tissues, stem cells need to maintain their populations in a faithful distribution of their epigenetic states, which are susceptible to stochastic fluctuations during each cell division, unexpected injury, and potential genetic mutations that occur during many cell divisions. However, it remains unclear how the three processes of differentiation, proliferation, and apoptosis in regulating stem cells collectively manage these challenging tasks. Here, without considering molecular details, we propose a genetic optimal control model for adult stem cell regeneration that includes th

SUBMITTER: Lei J 

PROVIDER: S-EPMC3956188 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature