A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool.

ABSTRACT:

Background

Glioblastoma multiforme (GBM) is the most frequent malignant brain tumor in adults, and its prognosis remains dismal despite intensive research and therapeutic advances. Diagnostic biomarkers would be clinically meaningful to allow for early detection of the tumor and for those cases in which surgery is contraindicated or biopsy results are inconclusive. Recent findings show that GBM cells release microvesicles that contain a select subset of cellular proteins and RNA. The aim of this hypothesis-generating study was to assess the diagnostic potential of miRNAs found in microvesicles isolated from the serum of GBM patients.

Methods

To control disease heterogeneity, we used patients with newly diagnosed GBM. In the discovery stage, PCR-based TaqMan Low Density Array

SUBMITTER: Manterola L 

PROVIDER: S-EPMC3956347 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature