Blockade of Kv1.3 channels ameliorates radiation-induced brain injury.

ABSTRACT:

Background

Tumors affecting the head, neck, and brain account for significant morbidity and mortality. The curative efficacy of radiotherapy for these tumors is well established, but radiation carries a significant risk of neurologic injury. So far, neuroprotective therapies for radiation-induced brain injury are still limited. In this study we demonstrate that Stichodactyla helianthus (ShK)-170, a specific inhibitor of the voltage-gated potassium (Kv)1.3 channel, protected mice from radiation-induced brain injury.

Methods

Mice were treated with ShK-170 for 3 days immediately after brain irradiation. Radiation-induced brain injury was assessed by MRI scans and a Morris water maze. Pathophysiological change of the brain was measured by immunofluorescence. Gene and protein exp

SUBMITTER: Peng Y 

PROVIDER: S-EPMC3956348 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature