Mutation profiling of the hepatitis B virus strains circulating in North Indian population.

ABSTRACT:

Aims

The aim of this study was to investigate the genomic mutations in the circulating Hepatitis B virus strains causing infection in the Indian population. Further, we wanted to analyze the biological significance of these mutations in HBV mediated disease.

Methods

222 HBsAg positive patients were enrolled in the study. The genotype and mutation profile was determined for the infecting HBV isolate by sequencing overlapping fragments. These sequences were analyzed by using different tools and compared with previously available HBV sequence information. Mutation Frequency Index (MFI) for the Genes and Diagnosis group was also calculated.

Results

HBV Genotype D was found in 55% (n = 121) of the patient group and genotype A was found in 30% (n = 66) of samples. The major

SUBMITTER: Tuteja A 

PROVIDER: S-EPMC3956465 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature