Differential expression of the insulin-like growth factor receptor among early breast cancer subtypes.

ABSTRACT:

Introduction

We sought to determine the level of protein expression of the critical components of the insulin-like growth factor receptor (IGFR) pathway and to evaluate their prognostic significance across the different early breast cancer subtypes.

Patients and methods

Archival tumor tissue from 1,021 women with early, node positive breast cancer, who were prospectively evaluated within two randomized clinical trials, was used to construct tissue microarrays that were stained for hormone receptors (HR), Ki67, HER2, epidermal growth factor receptor (EGFR) and cytokeratins 5/6, to classify tumors into five immunophenotypical subgroups. Immunohistochemical (IHC) expression of IGF1R-alpha and beta subunits, IGF2R and IGF-binding protein 2 (IGFBP2) was assessed using the immunor

SUBMITTER: Mountzios G 

PROVIDER: S-EPMC3956672 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature