Polymorphisms of DNA repair and oxidative stress genes in B-cell lymphoma patients.

ABSTRACT: The purpose of the study was to investigate the possible association between ERCC2 rs28365048, ERCC5 rs17655, XRCC3 rs861539 and NOS2A rs2297518 polymorphisms with B-cell lymphoma. The study was conducted on 189 patients with CD20⁺ B-cell lymphoma and 193 controls. The genotype frequencies were compared in the patient and control groups using quantitative polymerase chain reaction, based on allelic discrimination analysis. Our results indicated that variation in NOS2A may be significant in B-cell lymphoma in a population ≥50 years old (OR=2.15; 95% CI, 1.17-3.92; P=0.013). No association was observed between variations in ERCC2, ERCC5, XRCC3 and B-cell lymphoma in the studied population. Our finding of an association betwee

SUBMITTER: Fabisiewicz A 

PROVIDER: S-EPMC3956729 | biostudies-literature | 2013 Jan

REPOSITORIES: biostudies-literature