Tissue-specific gene expression and regulation in liver and muscle following chronic corticosteroid administration.

ABSTRACT: Although corticosteroids (CSs) affect gene expression in multiple tissues, the array of genes that are regulated by these catabolic steroids is diverse, highly tissue specific, and depends on their functions in the tissue. Liver has many important functions in performing and regulating diverse metabolic processes. Muscle, in addition to its mechanical role, is critical in maintaining systemic energy homeostasis and accounts for about 80% of insulin-directed glucose disposal. Consequently, a better understanding of CS pharmacogenomic effects in these tissues would provide valuable information regarding the tissue-specificity of transcriptional dynamics, and would provide insights into the underlying molecular mechanisms of action for both beneficial and detrimental effects. We performed an

SUBMITTER: Nguyen TT 

PROVIDER: S-EPMC3956809 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature