The functional therapeutic chemical classification system.

ABSTRACT:

Motivation

Drug repositioning is the discovery of new indications for compounds that have already been approved and used in a clinical setting. Recently, some computational approaches have been suggested to unveil new opportunities in a systematic fashion, by taking into consideration gene expression signatures or chemical features for instance. We present here a novel method based on knowledge integration using semantic technologies, to capture the functional role of approved chemical compounds.

Results

In order to computationally generate repositioning hypotheses, we used the Web Ontology Language to formally define the semantics of over 20 000 terms with axioms to correctly denote various modes of action (MoA). Based on an integration of public data, we have automatically

SUBMITTER: Croset S 

PROVIDER: S-EPMC3957075 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature