Bayesian network prior: network analysis of biological data using external knowledge.

ABSTRACT:

Motivation

Reverse engineering GI networks from experimental data is a challenging task due to the complex nature of the networks and the noise inherent in the data. One way to overcome these hurdles would be incorporating the vast amounts of external biological knowledge when building interaction networks. We propose a framework where GI networks are learned from experimental data using Bayesian networks (BNs) and the incorporation of external knowledge is also done via a BN that we call Bayesian Network Prior (BNP). BNP depicts the relation between various evidence types that contribute to the event 'gene interaction' and is used to calculate the probability of a candidate graph (G) in the structure learning process.

Results

Our simulation results on synthetic, simulated a

SUBMITTER: Isci S 

PROVIDER: S-EPMC3957076 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature