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Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network.

ABSTRACT: We here describe PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method, assessed biologically and statistically, enabled us to classify 11% of the Saccharomyces cerevisiae proteome into several groups, the majority of which contained proteins involved in the same biological process(es), and to predict a cellular function for many otherwise uncharacterized proteins.

SUBMITTER: Brun C 

PROVIDER: S-EPMC395738 | biostudies-literature | 2003

REPOSITORIES: biostudies-literature

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Functional classification of proteins for the prediction of cellular function from a protein-protein interaction network.

Brun Christine C   Chevenet François F   Martin David D   Wojcik Jérôme J   Guénoche Alain A   Jacq Bernard B  

Genome biology 20031215 1

We here describe PRODISTIN, a new computational method allowing the functional clustering of proteins on the basis of protein-protein interaction data. This method, assessed biologically and statistically, enabled us to classify 11% of the Saccharomyces cerevisiae proteome into several groups, the majority of which contained proteins involved in the same biological process(es), and to predict a cellular function for many otherwise uncharacterized proteins. ...[more]

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