Development and use of active clinical decision support for preemptive pharmacogenomics.

ABSTRACT:

Background

Active clinical decision support (CDS) delivered through an electronic health record (EHR) facilitates gene-based drug prescribing and other applications of genomics to patient care.

Objective

We describe the development, implementation, and evaluation of active CDS for multiple pharmacogenetic test results reported preemptively.

Materials and methods

Clinical pharmacogenetic test results accompanied by clinical interpretations are placed into the patient's EHR, typically before a relevant drug is prescribed. Problem list entries created for high-risk phenotypes provide an unambiguous trigger for delivery of post-test alerts to clinicians when high-risk drugs are prescribed. In addition, pre-test alerts are issued if a very-high risk medication is prescribe

SUBMITTER: Bell GC 

PROVIDER: S-EPMC3957400 | biostudies-literature | 2014 Feb

REPOSITORIES: biostudies-literature