A dynamic spatiotemporal extracellular matrix facilitates epicardial-mediated vertebrate heart regeneration.

ABSTRACT: Unlike humans, certain adult vertebrates such as newts and zebrafish possess extraordinary abilities to functionally regenerate lost appendages and injured organs, including cardiac muscle. Here, we present new evidence that a remodeled extracellular matrix (ECM) directs cell activities essential for cardiac muscle regeneration. Comprehensive mining of DNA microarrays and Gene Ontology term enrichment analyses for regenerating newt and zebrafish hearts revealed that distinct ECM components and ECM-modifying proteases are among the most significantly enriched genes in response to local injury. In contrast, data analyses for mammalian cardiac injury models indicated that inflammation and metabolic processes are the most significantly activated gene groups. In the regenerating newt heart, we

SUBMITTER: Mercer SE 

PROVIDER: S-EPMC3957425 | biostudies-literature | 2013 Oct

REPOSITORIES: biostudies-literature