Exploratory differential gene expression analysis in microarray experiments with no or limited replication.

ABSTRACT: We describe an exploratory, data-oriented approach for identifying candidates for differential gene expression in cDNA microarray experiments in terms of alpha-outliers and outlier regions, using simultaneous tolerance intervals relative to the line of equivalence (Cy5 = Cy3). We demonstrate the improved performance of our approach over existing single-slide methods using public datasets and simulation studies.

SUBMITTER: Loguinov AV 

PROVIDER: S-EPMC395768 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature