Addition of Escherichia coli K-12 growth observation and gene essentiality data to the EcoCyc database.

ABSTRACT: The sets of compounds that can support growth of an organism are defined by the presence of transporters and metabolic pathways that convert nutrient sources into cellular components and energy for growth. A collection of known nutrient sources can therefore serve both as an impetus for investigating new metabolic pathways and transporters and as a reference for computational modeling of known metabolic pathways. To establish such a collection for Escherichia coli K-12, we have integrated data on the growth or nongrowth of E. coli K-12 obtained from published observations using a variety of individual media and from high-throughput phenotype microarrays into the EcoCyc database. The assembled collection revealed a substantial number of discrepancies between the high-throughput data sets, w

SUBMITTER: Mackie A 

PROVIDER: S-EPMC3957686 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature