Type 1 fimbriae contribute to catheter-associated urinary tract infections caused by Escherichia coli.

ABSTRACT: Biofilm formation on catheters is thought to contribute to persistence of catheter-associated urinary tract infections (CAUTI), which represent the most frequent nosocomial infections. Knowledge of genetic factors for catheter colonization is limited, since their role has not been assessed using physicochemical conditions prevailing in a catheterized human bladder. The current study aimed to combine data from a dynamic catheterized bladder model in vitro with in vivo expression analysis for understanding molecular factors relevant for CAUTI caused by Escherichia coli. By application of the in vitro model that mirrors the physicochemical environment during human infection, we found that an E. coli K-12 mutant defective in type 1 fimbriae, but not isogenic mutants lacking flagella or antigen

SUBMITTER: Reisner A 

PROVIDER: S-EPMC3957706 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature