Physiological framework for the regulation of quorum sensing-dependent public goods in Pseudomonas aeruginosa.

ABSTRACT: Many bacteria possess cell density-dependent quorum-sensing (QS) systems that often regulate cooperative secretions involved in host-microbe or microbe-microbe interactions. These secretions, or "public goods," are frequently coregulated by stress and starvation responses. Here we provide a physiological rationale for such regulatory complexity in the opportunistic pathogen Pseudomonas aeruginosa. Using minimal-medium batch and chemostat cultures, we comprehensively characterized specific growth rate-limiting macronutrients as key triggers for the expression of extracellular enzymes and metabolites directly controlled by the las and rhl QS systems. Expression was unrelated to cell density, depended on the secreted product's elemental composition, and was induced only when the limiting nutr

SUBMITTER: Mellbye B 

PROVIDER: S-EPMC3957720 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature