Population genetic variation in gene expression is associated with phenotypic variation in Saccharomyces cerevisiae.

ABSTRACT:

Background

The relationship between genetic variation in gene expression and phenotypic variation observable in nature is not well understood. Identifying how many phenotypes are associated with differences in gene expression and how many gene-expression differences are associated with a phenotype is important to understanding the molecular basis and evolution of complex traits.

Results

We compared levels of gene expression among nine natural isolates of Saccharomyces cerevisiae grown either in the presence or absence of copper sulfate. Of the nine strains, two show a reduced growth rate and two others are rust colored in the presence of copper sulfate. We identified 633 genes that show significant differences in expression among strains. Of these genes, 20 were correlated w

SUBMITTER: Fay JC 

PROVIDER: S-EPMC395785 | biostudies-literature | 2004

REPOSITORIES: biostudies-literature