Reduced antimony accumulation in ARM58-overexpressing Leishmania infantum.

ABSTRACT: Antimony-based drugs are still the mainstay of chemotherapy against Leishmania infections in many countries where the parasites are endemic. The efficacy of antimonials has been compromised by increasing numbers of resistant infections, the basis of which is not fully understood and likely involves multiple factors. By using a functional cloning strategy, we recently identified a novel antimony resistance marker, ARM58, from the parasite Leishmania braziliensis that protects the parasites against antimony-based antileishmanial compounds. Here we show that the Leishmania infantum homologue also confers resistance against antimony but not against other antileishmanial drugs and that its function depends critically on one of four conserved domains of unknown function. This critical domain req

SUBMITTER: Schafer C 

PROVIDER: S-EPMC3957878 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature