Transcription factor Runx3 regulates interleukin-15-dependent natural killer cell activation.

ABSTRACT: Natural killer cells belong to the family of innate lymphoid cells comprising the frontline defense against infected and transformed cells. Development and activation of natural killer cells is highly dependent on interleukin-15 signaling. However, very little is known about the transcription program driving this process. The transcription factor Runx3 is highly expressed in natural killer cells, but its function in these cells is largely unknown. We show that loss of Runx3 impaired interleukin-15-dependent accumulation of mature natural killer cells in vivo and under culture conditions and pregnant Runx3(-/-) mice completely lack the unique population of interleukin-15-dependent uterine natural killer cells. Combined chromatin immunoprecipitation sequencing and differential gene expressio

SUBMITTER: Levanon D 

PROVIDER: S-EPMC3958033 | biostudies-literature | 2014 Mar

REPOSITORIES: biostudies-literature